Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Anti-hypoxia effects of ginseng (Panax Ginseng C A Meyer) oligopeptides in mice

Di Li^1,2, Jinwei Ren², JingQing Sun², Lan Wu², Peng Liu¹, Yong Li²

¹Department of Clinical Nutrition, Peking University People's Hospital, Beijing 100044; ²Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, PR China.

For correspondence:- Yong Li Email: ganxwjk140@163.com

Accepted: 24 June 2021 Published: 29 July 2021

Citation: Li D, Ren J, Sun J, Wu L, Liu P, Li Y. Anti-hypoxia effects of ginseng (Panax Ginseng C A Meyer) oligopeptides in mice. Trop J Pharm Res 2021; 20(7):1447-1454 doi: 10.4314/tjpr.v20i7.18

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To study the anti-hypoxia effects of ginseng oligopeptides (GOPs) in mice.

Methods: Mice were randomly assigned to six groups: vehicle control group, whey protein-fed group (0.30 g/kg body weight, BW), and four groups given GOP at doses of 0.075, 0.150, 0.300, 0.600 g/kg BW. All treatments were administered via gavage once a day for a total of 30 days.

Results: GOPs significantly extended survival times under normobaric hypoxia, sodium nitrite toxicosis and acute cerebral ischemia. Moreover, GOPs enhanced the levels of RBC, Hb and Hct; decreased brain malonaldehyde (MDA) and lactate contents, enhanced brain lactate dehydrogenase (LDH) activity, and upregulated the mRNA expression levels of hypoxia-inducible factor 1alpha (HIF1α) and vascular endothelial growth factor (VEGF).

Conclusion: GOPs exert anti-hypoxia effects via mechanisms which may involve improvement of oxygen-carrying capacity of blood and oxygen utilization, reduction of lipid peroxidation-associated lesions, enhancement of brain capacity to buffer against lactic acidosis, promotion of angiogenesis, and regulation of response to hypoxia.

Keywords: Ginseng; oligopeptide; anti-hypoxia; mice